Tag Archives: drugs

Development of Pharmaceuticals in the 20th Century

In 1900 the three main causes of death in the US were pneumonia, tuberculosis, and diarrhea. In 2000, the odds of dying from any one of these was 1 in 25 but only pneumonia remains in the list of the top 10 causes of death today. This can be attributed to the rise of better sanitation and vaccination techniques but the development of drugs also had a major role.

Pharmaceuticals began primarily with apothecary shops in the 19th century but a few preliminary drugs were discovered such as epinephrine, nor epinephrine, and barbiturates. In the post WWII period, several other antibiotics were produced and vaccines made for measles, rubella and mumps. Antihypertensive drugs and oral contraceptives were made as well. The Kefauver-Harris Amendment was passed in 1962 which enhanced drug regulation and forces manufacturers to prove that it was effective before a new drug went on market after thalidomide was shown to cause widespread birth defects in Europe. In the late 20th century statins such as simvastatin became a major development as they lowered cholesterol levels and reduced heart disease.

Overall the cost of the drug industry is extremely high. Industry wide research and investment cost $65.3 billion in 2009. It was also estimated that in 2003,  the cost for discovering, developing and launching a new drug over a 5 year period is $1.3 billion. However by 2010, development costs range from $4 billion to $11 billion per drug.

–Julia Ng

Pharmacology in the 20th C

Medical advances were abundant during the 20th century, with major breakthroughs in technology, chemistry, biology, and pharmacology that overlapped to eradicate many diseases. Over the course of the 20th century, drugs to treat illness such as aspirin, the arsenic-based compound Salvarsin to treat syphilis, antibioitcs such as penicillin, steroid hormones such as cortisone were discovered and found to be effective in treating a multitude of fatal and nonfatal illnesses. In addition, the first antiviral vaccines were discovered, including smallpox and polio. These advances lead to drastic improvement in collective health and life expectancy, and fatal diseases like pneumonia and tuberculosis that lead to roughly one-third of all deaths in 1900 are rare in the US now. While some drugs had basis in natural techniques that had been around for centuries, the 20th century also saw the rise of synthesizing new, unnatural drugs often by the process of computer-aided design (CAD).

In response to the multitude of drugs being tested and put unto place came regulation of drugs by government agencies. Over time, drug laws and regulatory agencies have expanded, sometimes in response to health crises caused by the release of a drug. Drugs are now analyzed in their performance in clinical trials, in terms of their risk-to-benefit ratios, mutagenicity, teratogenicity (cancer-causing) and other factors. The climate of medical change accompanied by major advances in science and technology had large implications on culture and society.

– Lauren Hodgson

Sources:

http://www.planetseed.com/relatedarticle/20th-century-and-drugs-treat-sicknesses

http://www.pharmsci.uci.edu/history.php

http://www.britannica.com/topic/pharmaceutical-industry/Drug-discovery-and-development